John F. Butzer Center for Research & Innovation

Active recruitment opportunities include:

Sleep for Stroke Management and Recovery Trial (Sleep SMART)
Mary Free Bed is participating in the Stroke Net study Sleep SMART. This 110-site study randomizes participates who have sleep apnea to test whether treatment of obstructive sleep apnea with continuous positive airway pressure (CPAP) is effective for secondary prevention and recovery after stroke. Eligible participants must be referred from acute care and receiving inpatient therapeutic services for a stroke diagnosis. For more information, click here.

Bone Health Biobank
Researchers are collecting saliva samples from Mary Free Bed patients who have a bone health diagnosis. Genetic mapping will be done to assess relationships with specific gene profiles and diagnoses. Results may contribute to changes in clinical practice and treatment of diagnoses, such as osteoarthritis and osteopenia. Eligible participants must have a bone-related diagnosis and be treated at Mary Free Bed.

Concentrations of Interleukin-1 Family Members in Synovial Fluid
Mary Free Bed residents are collecting synovial fluid from patients who have osteoarthritis. Synovial fluid samples will be characterized to assess the genetic relationship between OA and gene sequencing. Eligible participants must have an OA diagnosis and be treated in a Mary Free Bed outpatient clinic.

Defining Trajectories of Linguistic, Cognitive-Communicative and Quality of Life Outcomes in Aphasia
The objective of this study is to describe the trajectories of linguistic, cognitive-communicative and health-related quality of life outcomes following stroke in people with aphasia during inpatient and outpatient rehabilitation to 18 months following their stroke. A sample of 300 consecutively admitted stroke patients with aphasia recruited at three Midwest rehabilitation hospitals will complete measures of linguistic and cognitive-communicative performance and the Quality of Life Neurological Disorders Measurement instruments during rehabilitation and at three-, six-, 12- and 18-months post stroke. We will model outcomes as individual and group trajectories, allowing us to develop individual predictions that could inform clinical planning and decision-making for new patients. For more information, click here.

Patient Population Assessment and Functional Outcome Measure of Post Coronavirus Disease (COVID-19) in an Inpatient Rehabilitation Facility
Researchers at Mary Free Bed are mapping out and describing the functional outcome status of people who had/have COVID-19 for up to six months post-positive diagnosis. Eligible participants must be enrolled from inpatient rehabilitation.

The Role of Music Therapy in Visuospatial Neglect
Researchers are evaluating the potential benefit of musical neglect training in people with left-sided visuospatial neglect secondary to a right hemisphere stroke. Eligible participants must be enrolled from inpatient rehabilitation.

Interluekin-1 Family Members in COVID-19
Researchers will be collecting blood samples from Mary Free Bed patients who have/had a COVID-19 diagnosis. They will be assessing the inflammatory response associated with IL-1 and COVID-19.

Winding down:
Increasing Physical Activity and Health Related Quality of Life for Persons with Spinal Cord Injury
Mary Free Bed Rehabilitation Hospital was awarded a three-year, $400,000 grant from the Craig H. Neilsen Foundation to measure how physical activity impacts the lives of people with spinal cord injury.
Researchers are currently assessing exercise compliance and quality of life. Recruitment closed.

Long-term Modeling of Stroke Rehabilitation Outcomes from Acute Care to Community Living
Recruitment closed.

Short-term Modeling of Stroke Outcome Trajectories During Inpatient Rehabilitation
Recruitment closed.

Mary Free Bed Institutional Review Board requirements:

• Adverse Event Report
• Amendment Request
• Continuing Review
• FCOI Disclosure
• IRB Application for Initial Review
• Notification of Study Closure
• Serious Adverse Event Report

 

The Mary Free Bed IRB requires the following Epigeum, Collaborative Institutional Training Initiative (CITI), MSU Saba, UM PEERRS or equivalent:

• Responsible Conduct of Research
• Human Subject Protections
• Financial Conflict of Interest

 

For access to trainings or forms, please email irbadmin@maryfreebed.com.

 

 

Mary Free Bed is committed to becoming a Learning Health System, an organization that engages and includes all workforce members to improve clinical and administrative processes with the goal of creating beneficial outcomes for patients. Our goal is to have a fluid system for reporting, evaluating, trialing, engaging and implementing from all corners of the Mary Free Bed Rehabilitation Network.

This iterative system will build on strengths already associated with Mary Free Bed: our data warehouse, experienced and compassionate workforce, and our engagement in the communities we serve. To learn more, email research@maryfreebed.com.

Medical students

The John F. Butzer Center for Research and Innovation works collaboratively with medical students to teach, empower and facilitate growth. Our studies incorporate the skills of medical students to assist with study outcomes and objectives.

• Michigan State University College of Human Medicine medical students interested in participating in research at Mary Free Bed should contact MSU-CHM student research director Mark Trottier, Ph.D., at trottie1@msu.edu or 616.234.2781.
• Medical students who attend other schools and are interested in research opportunities at Mary Free Bed should email research@maryfreebed.com. You also may contact our Education Department at education@maryfreebed.com or 616.840.8292.

Researchers
Research Education for Clinicians & Professionals (RECaP) Seminar Series
The RECaP Seminar Series provides a framework for clinicians interested in developing a research question into a proposal. The 12-week Seminar Series provides facilitated discussions on a topic of the week along with opportunities to problem-solve related sections of participants’ proposals. Between each seminar series, participants also are expected to complete readings and draft sections of their proposals that relate to the weekly topic. Following the last session, participants will have drafted complete research proposals, which can be submitted to the Investigator Award competition held by the Center for Research & Innovation to an external grant funding agency or, in some cases, may be implemented without grant funding. The Seminar Series runs from September to December.

Investigator Award
Mary Free Bed Rehabilitation Hospital strives to contribute to new knowledge in rehabilitation and neuroscience through collaborative research and to translate the results into evidence-based guidelines for clinical practice.  The Mary Free Bed Investigator Award provides funding for up to $10,000. These funds are intended to provide protected release time for clinicians, finance participant stipends and cover travel and presentation costs. Investigator Awards will be granted following a merit-based, competitive process.  Examples of projects that may qualify include prospective research, archival/retrospective research, manuscript preparation from previously completed data collection or comprehensive review of literature and systematic outcomes analyses for Mary Free Bed equipment/program(s).

 

Application deadlines:
1. Announcement for submissions: October
2. Application deadline: December
3. Awardee announcement: January
4. Grant start date: April

Post-Doctoral Opportunities
The Center for Research and Innovation is pursuing funding opportunities to support post-doctoral candidates in the domains of Community Living and Participation, Employment and Health and Function. Please check back for updates.

Mary Free Bed has the pleasure of serving patients and their families throughout the state of Michigan. To better meet the needs of our patients and the communities we serve, we developed a registry system to create efficient access to past and current patients who may be interested in or benefit from active research studies or quality improvement projects. If you’d like to be added to one of our registries, please email research@maryfreebed.com with your name and contact information.

Our registries include:

1. Spinal Cord Injury Registry
2. Stroke Registry
3. Traumatic Brain Injury Registry
4. Pediatric Registry

Research Advisory Council
Charged with setting the strategic direction for clinical research that supports Mary Free Bed’s mission, the advisory council also identifies and builds key relationships with collaborators and other institutions that broaden and advance our ability to deliver innovative treatment and care for patients.

Michael Jakubowski, M.D.
Chief Medical Officer

Craig Webb, Ph.D.
Consultant

John F. Butzer, M.D.
Research Director Emeritus

Center for Research & Innovation
Allan J. Kozlowski
Director, Outcomes Research

Ashley Fife
Institutional Review Board Coordinator

Jacob Cobb
Research Assistant

Jennifer Dowsett
Administrative Assistant

Kelsey Boersma
Project Manager, Center for Research + Innovation, Business Intelligence + Informatics

Michelle Bassett
Director, Research Administration

Rebecca Cistaro
Director, Business Intelligence and Informatics

 

John F. Butzer Center for Research and Innovation staff publications:

Dr. John F. Butzer, M.D.

Butzer, J.F., Kozlowski, A.J. and Virva, R. (2018). Measuring Value in Post-acute Care. Arch Phys Med Rehabil. doi:10.1016/j.apmr.2018.11.008

Ballard, E., Butzer, J.F., and Donders, J. (1996). Susac’s syndrome: neuropsychological characteristics in a young man. Neurology, 47(1), 266-268.

Gleeson, R.K., Butzer, J.F. and Grin, O.D., Jr. (1978). Acoustic neurinoma presenting as subarachnoid hemorrhage. Case report. J Neurosurg, 49(4), 602-604. doi:10.3171/jns.1978.49.4.0602

Butzer, J.F., Cancilla, P.A. and Cornell, S.H. (1976). Computerized axial tomography of intracerebral hematoma. A clinical and neuropathological study. Arch Neurol, 33(3), 206-214.

Butzer, J.F., Cancilla, P.A. and Cornell, S.H. (1975). Computerized axial tomography of intracerebral hemorrhage: a clinical and neuropathologic study. Trans Am Neurol Assoc, 100, 35-38.

Butzer, J.F., Schochet, S.S., Jr. and Bell, W.E. (1975). Infantile neuroaxonal dystrophy. An electron microscopic study of a case clinically resembling neuronal ceroid-lipofuscinosis. Acta Neuropathol, 31(1), 35-43.

Butzer, J.F., Silver, D.E. and Sahs, A.L. (1975). Amantadine in Parkinson’s disease. A double-blind, placebo-controlled, crossover study with long-term follow-up. Neurology, 25(7), 603-606.

Butzer, J.F. and Van Allen, M.W. (1975). Transient ischemic attacks. Compr Ther, 1(8), 31-35.

Kimura, J. and Butzer, J.F. (1975). F-wave conduction velocity in Guillain-Barre syndrome. Assessment of nerve segment between axilla and spinal cord. Arch Neurol, 32(8), 524-529.

Kimura, J., Butzer, J.F. and Van Allen, M. W. (1974). F-wave conduction velocity between axilla and spinal cord in the Guillain-Barre syndrome. Trans Am Neurol Assoc, 99, 52-62.

Craig P. Webb, Ph.D.

Monsma D.J., Cherba D.M., Eugster E.E., Dylewski D.L., Davidson P.T., Peterson C.A., Borgman A.S., Winn M.E., Dykema K.J., Webb C.P., MacKeigan J.P., Duesbery N.S., Nickoloff B.J. and Monks N.R. (2015). Melanoma patient derived xenografts acquire distinct Vemurafenib resistance mechanisms. Am. J. Cancer Res. 5:1507.

David J Monsma, David M Cherba, Patrick J Richardson, Sean Vance, Sanjeet Rangarajan, Dawna Dylewski, Emily Eugster, Stephanie B. Scott, Nicole L Beuschel, Paula J. Davidson, Richard Axtell, Deanna Mitchell, Eric P. Lester, Joseph J. Junewick, Noel R. Monks and Craig P. Webb (2014). Using a rhabdomyosarcoma patient‐derived xenograft to examine precision medicine approaches and model acquired resistance. Pediatric blood & cancer 61: 1570.

Wendi V. Rodrigueza, Michael J. Woolliscroft, Abdul-Shukkur Ebrahim, Robert Forgey, Patrick J. McGovren, Gerold Endert, Andreas Wagner, Danielle Holewa, Amro Aboukameel, Richard D. Gill, Charles L. Bisgaier, Richard A. Messmann, Christopher E. Whitehead, Elzbieta Izbicka, Robert Streeper, Michael C. Wick, Gabriela Stiegler, CA Stein, David Monsma, Craig Webb, Mina P. Sooch, Steffen Panzner, Ramzi Mohammad, Neal C. Goodwin and Ayad Al-Katib (2014). Development and antitumor activity of a BCL-2 targeted single-stranded DNA oligonucleotide. Cancer chemotherapy and pharmacology 74: 151.

Artem D. Berezovsky, Laila M. Poisson, David Cherba, Craig P. Webb, Andrea D. Transou, Nancy W. Lemke, Xin Hong, Laura A. Hasselbach, Susan M. Irtenkauf and Tom Mikkelsen (2014). Sox2 promotes malignancy in glioblastoma by regulating plasticity and astrocytic differentiation. Neoplasia 16: 193.

Craig Webb, Melissa Paoloni, Christina Mazcko, David Cherba, William Hendricks, Susan Lana, EJ Ehrhart, Brad Charles, Heather Fehling, Leena Kumar, David Vail, Michael Henson, Michael Childress, Barbara Kitchell, Christopher Kingsley, Seungchan Kim, Mark Neff, Barbara Davis, Chand Khanna and Jeffrey Trent (2014). PloS one 9: e90028.

Jacqueline .D Peacock, David Cherba, Kevin Kampfschulte, Mallory K. Smith, Noel R. Monks, Craig P. Webb, Matthew Steensma (2013). Molecular-guided therapy predictions reveal drug resistance phenotypes and treatment alternatives in malignant peripheral nerve sheath tumors. J. Trans. Med. 11: 213.

Noel R Monks, David M Cherba, Steven G Kamerling, Heather Simpson, Anthony W Rusk, Derrick Carter, Emily Eugster, Marie Mooney, Robert Sigler, Matthew Steensma, Tessa Grabinski, Keith R Marotti and Craig P Webb. (2013). A multi-site feasibility study for personalized medicine in canines with Osteosarcoma. J. Trans. Med. 11: 158.

Marie Mooney, Jeffrey Bond, Noel Monks, Emily Eugster, David Cherba, Pamela Berlinski, Steve Kamerling, Keith Marotti, Heather Simpson, Tony Rusk, Waibhav Tembe, Christophe Legendre, Hollie Benson, Winnie Liang, and Craig Webb (2013). Comparative RNA-Seq and microarray analysis of gene expression changes in B-Cell lymphomas of Canis familiaris. PLoS ONE 8(4), e61088.

Saulnier Sholler, Giselle L., William Ferguson, Genevieve Bergendahl, Erika Currier, Shannon R. Lenox, Jeffrey Bond, Marni Slavik, William Roberts, Deanna Mitchell, Don Eslin, Jacqueline Kraveka, Joel Kaplan, Nehal Parikh, Suman Malempati, Gina Hanna, Emily Eugster, David Cherba, Jeremy Miller, and Craig Webb (2012). A pilot trial testing the feasibility of using molecular-guided therapy in patients with recurrent neuroblastoma. Journal of Cancer Therapy 3: 602.

Monsma, David J., Noel R. Monks, David M. Cherba, Dawna Dylewski, Emily Eugster, Jahn Hailey, Sujata Srikanth, Stephanie B. Scott, Patrick J. Richardson, Robin E. Everts, Aleksandr Ishkin, Yuri Nikolsky, James H. Resau, Robert Sigler, Brian J. Nickoloff, and Craig P. Webb (2012). Genomic characterization of explant tumorgraft models derived from fresh patient tumor tissue. Journal of Translational Medicine 10: 125.

Lee Chih-Shia, Karl J. Dykema, Danielle M. Hawkins, David M. Cherba, Craig P. Webb, Kyle J. Furge and Nicholas Duesbery. (2011) MEK2 is sufficient but not necessary for proliferation and anchorage-independent growth of SK-MEL-28 melanoma cells. PLoS ONE 6(2): e17165.

Phadke, Anagha P., Chris M. Jay, Zhaohui Wang, Salina Chen, Shengnan Liu, Courtney Haddock, Padmasini Kumar, Beena O. Pappen, Donald D. Rao, Nancy S. Templeton, Egeenee Q. Daniels, Craig P. Webb, David Monsma, Stephanie Scott, Dawna Dylewski, Hermann B. Frieboes, Francis Charles Brunicardi, Neil Senzer, Phillip B. Maples, John Nemunaitis, and Alex W. Tong (2011). In vivo safety and antitumor efficacy of bifunctional small hairpin RNAs specific for the human stathmin 1 oncoprotein. DNA Cell Biology. 30(9): 715.

Dieterle F., Sistare F., Goodsaid F., Papaluca M., Ozer J.S., Webb C.P., Baer W., Senagore A., Schipper M.J., Vonderscher J., Sultana S, Gerhold D.L., Phillips J.A., Maurer G., Carl K., Laurie D., Harpur E., Sonee M., Ennulat D., Holder D., Andrews-Cleavenger D., Gu Y.Z., Thompson K.L., Goering P.L., Vidal J.M., Abadie E., Maciulaitis R., Jacobson-Kram D, Defelice A.F., Hausner E.A., Blank M, Thompson A., Harlow P., Throckmorton D., Xiao S., Xu N., Taylor W, Vamvakas S., Flamion B, Lima B.S., Kasper P., Pasanen M., Prasad K., Troth S, Bounous D, Robinson-Gravatt D., Betton G., Davis M.A, Akunda J., McDuffie J.E., Suter L., Obert L., Guffroy M., Pinches M., Jayadev S., Blomme E.A., Beushausen S.A., Barlow V.G., Collins N., Waring J., Honor D., Snook S., Lee J., Rossi P., Walker E., Mattes W (2010).  Renal biomarker qualification submission: A dialog between the FDA/EMEA and Predictive Safety Testing Consortium. Nature Biotechnology. 28(5): 455.

Maupin, K.A., Sinha, A., Eugster, E., Miller, J., Ross, J., Paulino, V., Keshamouni, V.G., Tran, N., Berens, M., Webb, C., Haab, B.B. (2010). Glycogene expression alterations associated with pancreatic cancer epithelial-mesenchymal transition in complementary model systems. PLoS One. 5(9):e13002.

Melnik, Marianne K., Craig P. Webb, Patrick J. Richardson, Charles R. Luttenton, Alan D. Campbell, Thomas J. Monroe, Timothy J. O’Rourke, Kathleen J. Yost, Connie M. Szczepanek, Michelle R. Bassett, Kimberly J. Truszkowski, Phyllis Stein, Matthew W. VanBrocklin Alan T. Davis, Gabriela Bedolla, George F. Vande Woude, and Han-Mo Koo (2010). Phase II trial to evaluate gemcitabine and Etoposide for locally advanced or metastatic pancreatic cancer. Molecular Cancer Therapeutics 9(8): 2423.

Ranade, Aarati R., David Cherba, Shravan Sridhar, Patrick Richardson, Craig Webb, Anoor Paripati, Brad Bowles, Glen J. Weiss (2010).  MicroRNA 92a-2*, a biomarker predictive for chemoresistance and prognostic for survival in patients with small cell lung cancer. Journal of Thoracic Oncology 5(8): 1273.

Rao, D.D., P.B. Maples, N. Senzer, P. Kumar, Z. Wang, B.O. Pappen, Y. Yu, C. Haddock, C. Jay, A.P. Phadke, S. Chen, J. Kuhn, D. Dylewski, S. Scott, David J. Monsma, Craig Webb, A. Tong, D. Shanahan, and J. Nemunaitis (2010).  Enhanced target gene knockdown by a bifunctional shRNA: a novel approach of RNA interference.  Cancer Gene Therapy 17(11): 780.

Sistare Frank D., Frank Dieterle, Sean Troth, Daniel J. Holder, David Gerhold, Dina Andrews-Cleavenger, William Baer, Graham Betton, Denise Bounous, Kevin Carl, Nathaniel Collins, Peter Goering, Federico Goodsaid, Yi-Zhong Gu, Valerie Guilpin, Ernie Harpur, Alita Hassan, David Jacobson-Kram, Peter Kasper, David Laurie, Beatriz Silva Lima, Romaldas Maciulaitis, William Mattes, Gerard Maurer, Leslie Ann Obert, Josef Ozer, Marisa Papaluca-Amati, Jonathan A. Phillips, Mark Pinches, Matthew J. Schipper, Karol K. Thompson, Spiros Vamvakas, Jean-Marc Vidal, Jacky Vonderscher, Elizabeth Walker, Craig Webb, Yan Yu (2010). Towards consensus practices to qualify new safety biomarkers for use in early drug development. Nature Biotechnology. 28(5): 446.

Wang, Xiaoting, Shuangshuang Wang, Xiaojun Tang, Aixia Zhang, Tessa Grabinski, Zhenying Guo, Eric Hudson, Bree Berghuis, Craig Webb, Ping Zhao, Brian Cao (2010).  Development and evaluation of monoclonal antibodies against phosphatidylethanolamine binding protein 1 in pancreatic cancer patients. Journal of Immunological Methods 362(1-2): 151.

Dezso Z., Nikolsky Y., Nikolskaya T., Miller J., Cherba D., Webb C., Bugrim A (2009). Identifying disease-specific genes based on their topological significance in protein networks, BMC Systems Biology 3(1): 36.

Ivanov, S.V., J. Miller, R. Lucito, C. Tang, A.V. Ivanova, J. Pei, M. Carbone, C. Cruz, A. Beck, C. Webb, D. Nonaka, J.R. Testa, and H.I. Pass (2009). Genomic events associated with progression of pleural malignant mesothelioma. International Journal of Cancer 124(3): 589.

Kuick, R., D.E. Misek, D.J. Monsma, C.P. Webb, H. Wang, K.J. Peterson, M. Pisano, G.S. Omenn and S.M. Hanash (2007).  Discovery of cancer biomarkers through use of mouse models. Cancer Letters 249(1): 40.

Ubels, J.L., H.M. Hoffman, S. Srikanth, J.H. Resau and C.P. Webb (2006).  Gene expression in rat lacrimal gland duct cells collected using laser capture microdissection: evidence for K+ secretion by duct cells.  Investigative Ophthalmology and Visual Science 47(5): 1876.

Bromann, P.A., H. Korkaya, C.P. Webb, J. Miller, T.L. Calvin, and S.A. Courtneidge (2005). Platelet-derived growth factor stimulates Src-dependent mRNA stabilization of specific early gene in fibroblasts.  Journal of Biological Chemistry 280(11): 10253.

Creighton, C.J., J.L. Bromberg-White, D.E. Misek, D.J. Monsma, F. Brichory, R. Kuick, T.J. Giordano, W. Gao, G.S. Omenn, C.P. Webb, and S.M. Hanash (2005). Analysis of tumor-host interactions by gene expression profiling of lung adenocarcinoma xenografts identifies genes involved in tumor formation.  Molecular Cancer Research 3(3): 119.

Pass, H. I., D. Lott, F. Lonardo, M. Harbut, Z. Liu, N. Tang, M. Carbone, C.P. Webb, and A. Wali (2005).  Asbestos exposure, pleural mesothelioma, and serum osteopontin levels. New England Journal of Medicine 353(15): 1564.

Bromberg-White, J.L., C.P. Webb, S.L. Holmen, V.S. Patacsil, C.K. Miranti and B.O. Williams (2004).  Delivery of short hairpin RNA sequences by using a replication-competent avian retroviral vector.  Journal of Virology 78(9): 4914.

Miller, J., J. Bromberg-White, K. DuBois, E. Eugster, S. Srikanth, R. Haddad, C. DeLeeuw, and C.P. Webb (2003).  Identification of metastasis-associated targets in a murine model of ras-mediated fibrosarcomas.  Journal of Applied Genomics and Proteomics 2(4): 253.

Haddad, R., K. Furge, J. Miller, J. Schouman, B.T. Teh, B. Haab, L. Barr, and C.P. Webb (2002).  Genomic profiling and cDNA microarray analysis of human colon adenocarcinoma and associated intraperitoneal metastases reveals consistent cytogenetic and transcriptional aberrations associated with progression of multiple metastases.  Journal of Applied Genomics and Proteomics 1(2): 123.

Duesbery, N.S., J. Resau, C.P. Webb, S. Koochekpour, H.-M. Koo, S.H. Leppla, and G. F. Vande Woude (2001).  Suppression of ras-mediated transformation and inhibition of tumor growth and angiogenesis by anthrax lethal factor, a proteolytic inhibitor of multiple MEK pathways. Proceedings of the National Academy of Sciences U.S.A. 98(7): 4089.

Furge, K.A., D. Kiewlich, P. Le, M.N. Vo, K.E. Lipson, M. Faure, A.R. Howlett, G.F. Vande Woude, and C.P. Webb (2001).  Suppression of ras-mediated tumorigenicity and metastasis through inhibition of the Met receptor tyrosine kinase. Proceedings of the National Academy of Sciences U.S.A. 98(19): 10722.

Gmyrek, G.A., M. Walburg, C.P. Webb, H.-M. Koo, X. You, D. Vaughan, G.F. Vande Woude, and B.S. Knudsen (2001).  Normal and malignant prostate epithelial cells differ in their response to hepatocyte growth factor/scatter factor.  American Journal of Pathology 159(2): 579.

Webb, C.P., C.D. Hose, S. Koochekpour, M. Jeffers, M. Oskarsson, E Sausville, A. Monks, and G.F. Vande Woude (2000).  The geladanamycins are potent inhibitors of the hepatocyte growth factor/scatter factor-met-urokinase plasminogen activator-plasmin proteolytic network.  Cancer Research 60: 342.

Jeffers, M., M. Fiscella, C.P. Webb, M. Anver, S. Koochekpour, and G.F. Vande Woude (1998).  The mutationally activated Met receptor mediates motility and metastasis.  Proceedings of the National Academy of Science U.S.A. 95: 8773.

Webb, C.P., G.A. Taylor, M. Jeffers, J. Resau, and G.F. Vande Woude (1998).  Evidence for a role of Met-HGF/SF during Ras-mediated tumorigenicity and metastasis.  Oncogene 17: 2019.

Taylor, G.A., M. Jeffers, C.P. Webb, H.-M. Koo, M. Anver, A. Roberts, and G.F. Vande Woude (1998).  Decreased fibronectin expression in Met/HGF-mediated tumorigenesis.  Oncogene 17: 1179.

Webb, C.P., L. Van Aelst, M.H. Wigler, and G.F. Vande Woude (1998).  Signaling pathways in Ras-mediated tumorigenicity and metastasis.  Proceedings of the National Academy of Science U.S.A. 95: 8773.

Duesbery, N.S., C.P. Webb, S.H. Leppla, V.M. Gordon, K.R. Klimpel, T.D. Copeland, N.G. Ahn, K. Fukasawa, K.D. Paull, and G.F. Vande Woude (1998).  Anthrax lethal factor is a MAP-kinase kinase protease.  Science 280: 734.

Jeffers, M., L. Schmidt, N. Nakaigawa, C.P. Webb, G. Weirich, T. Kishida, B. Zbar, and G.F. Vande Woude (1997).  Activating mutations for the Met tyrosine kinase receptor in human cancer.  Proceedings of the National Academy of Science U.S.A. 94: 11445.

Webb, C.P., K. Lane, A.P. Dawson, G.F. Vande Woude, and R.M. Warn (1996).  C-Met signaling in an HGF/SF-insensitive variant MDCK cell line with constitutive motile/invasive behavior.  Journal of Cell Science 109: 2371.

Smith, J.A.M., C. Webb, J. Holford, and G.M. Burgess (1995).  Signal transduction pathways for B1 and B2 bradykinin receptors in bovine pulmonary artery endothelial cells.  Molecular Pharmacology 47: 525.

 

Allan J. Kozlowski, Ph.D.

Butzer, J.F., Kozlowski, A.J. and Virva, R. (2018). Measuring Value in Postacute Care. Arch Phys Med Rehabil. doi:10.1016/j.apmr.2018.11.008

Kozlowski, A. J., Fabian, M., Lad, D. and Delgado, A. D. (2017). Feasibility and Safety of a Powered Exoskeleton for Assisted Walking for Persons With Multiple Sclerosis: A Single-Group Preliminary Study. Arch Phys Med Rehabil, 98(7), 1300-1307. doi:10.1016/j.apmr.2017.02.010

Pretz, C.R., Kozlowski, A. J., Chen, Y., Charlifue, S. and Heinemann, A. W. (2016). Trajectories of Life Satisfaction After Spinal Cord Injury. Arch Phys Med Rehabil, 97(10), 1706-1713 e1701. doi:10.1016/j.apmr.2016.04.022

Pretz, C. R., Kean, J., Heinemann, A.W., Kozlowski, A.J., Bode, R.K. and Gebhardt, E. (2016). A Multidimensional Rasch Analysis of the Functional Independence Measure Based on the National Institute on Disability, Independent Living, and Rehabilitation Research Traumatic Brain Injury Model Systems National Database. J Neurotrauma, 33(14), 1358-1362. doi:10.1089/neu.2015.4138

Kozlowski, A.J., Cella, D., Nitsch, K.P. and Heinemann, A.W. (2016). Evaluating Individual Change With the Quality of Life in Neurological Disorders (Neuro-QoL) Short Forms. Arch Phys Med Rehabil, 97(4), 650-654 e658. doi:10.1016/j.apmr.2015.12.010

Kolski, M.C., O’Connor, A., Van Der Laan, K., Lee, J., Kozlowski, A.J. and Deutsch, A. (2016). Validation of a pain mechanism classification system (PMCS) in physical therapy practice. J Man Manip Ther, 24(4), 192-199. doi:10.1179/2042618614Y.0000000090

Taylor, S., Gassaway, J., Heisler-Varriale, L.A., Kozlowski, A.J., Teeter, L., Labarbera, J., Swirsky, A. (2015). Patterns in Wheeled Mobility Skills Training, Equipment Evaluation, and Utilization: Findings from the SCIRehab Project. Assist Technol, 27(2), 59-68. doi:10.1080/10400435.2014.978511

Kozlowski, A..J., Singh, R., Victorson, D., Miskovic, A., Lai, J. S., Harvey, R.L., Heinemann, A.W. (2015). Agreement Between Responses from Community-Dwelling Persons With Stroke and Their Proxies on the NIH Neurological Quality of Life (Neuro-QoL) Short Forms. Arch Phys Med Rehabil, 96(11), 1986-1992 e1914. doi:10.1016/j.apmr.2015.07.005

Kozlowski, A.J., Bryce, T.N. and Dijkers, M.P. (2015). Time and Effort Required by Persons with Spinal Cord Injury to Learn to Use a Powered Exoskeleton for Assisted Walking. Top Spinal Cord Inj Rehabil, 21(2), 110-121. doi:10.1310/sci2102-110

Bryce, T.N., Dijkers, M.P. and Kozlowski, A.J. (2015). Framework for Assessment of the Usability of Lower-Extremity Robotic Exoskeletal Orthoses. Am J Phys Med Rehabil, 94(11), 1000-1014. doi:10.1097/PHM.0000000000000321

Pretz, C.R., Kozlowski, A.J., Charlifue, S., Chen, Y. and Heinemann, A.W. (2014). Using Rasch motor FIM individual growth curves to inform clinical decisions for persons with paraplegia. Spinal Cord, 52(9), 671-676. doi:10.1038/sc.2014.94

Hart, T., Kozlowski, A.J., Whyte, J., Poulsen, I., Kristensen, K., Nordenbo, A. and Heinemann, A.W. (2014). Functional recovery after severe traumatic brain injury: an individual growth curve approach. Arch Phys Med Rehabil, 95(11), 2103-2110. doi:10.1016/j.apmr.2014.07.001

Bode, R.K., Heinemann, A.W., Kozlowski, A.J. and Pretz, C.R. (2014). Self-scoring templates for motor and cognitive subscales of the FIM instrument for persons with spinal cord injury. Arch Phys Med Rehabil, 95(4), 676-679 e675. doi:10.1016/j.apmr.2013.11.009

Kozlowski, A.J. and Heinemann, A.W. (2013). Using individual growth curve models to predict recovery and activities of daily living after spinal cord injury: an SCIRehab project study. Arch Phys Med Rehabil, 94(4 Suppl), S154-164 e151-154. doi:10.1016/j.apmr.2012.11.050

Pretz, C.R., Kozlowski, A.J., Dams-O’Connor, K., Kreider, S., Cuthbert, J.P., Corrigan, J.D., Whiteneck, G. (2012). Descriptive Modeling of Longitudinal Outcome Measures in Traumatic Brain Injury: A National Institute on Disability and Rehabilitation Research Traumatic Brain Injury Model Systems Study. Arch Phys Med Rehabil. doi:10.1016/j.apmr. 2012.08.197

Kozlowski, A.J., Pretz, C.R., Dams-O’Connor, K., Kreider, S. and Whiteneck, G. (2012). An Introduction to Applying Individual Growth Curve Models to Evaluate Change in Rehabilitation: A National Institute on Disability and Rehabilitation Research Traumatic Brain Injury Model Systems Report. Arch Phys Med Rehabil. doi:10.1016/j.apmr.2012.08.199

Hunt, D.G., Zuberbier, O.A., Kozlowski, A.J., Berkowitz, J., Schultz, I.Z., Milner, R.A., Turk, D.C. (2002). Are components of a comprehensive medical assessment predictive of work disability after an episode of occupational low back trouble? Spine (Phila Pa 1976), 27(23), 2715-2719. doi:10.1097/01.BRS.0000035322.34680.16

Zuberbier, O.A., Kozlowski, A.J., Hunt, D.G., Berkowitz, J., Schultz, I.Z., Crook, J.M. and Milner, R.A. (2001). Analysis of the convergent and discriminant validity of published lumbar flexion, extension, and lateral flexion scores. Spine (Phila Pa 1976), 26(20), E472-478.

Zuberbier, O.A., Hunt, D.G., Kozlowski, A.J., Berkowitz, J., Schultz, I. Z., Crook, J.M. and Milner, R.A. (2001). Commentary on the American Medical Association guides’ lumbar impairment validity checks. Spine (Phila Pa 1976), 26(24), 2735-2737.

Hunt, D.G., Zuberbier, O.A., Kozlowski, A.J., Robinson, J., Berkowitz, J., Schultz, I.Z., Turk, D.C. (2001). Reliability of the lumbar flexion, lumbar extension, and passive straight leg raise test in normal populations embedded within a complete physical examination. Spine (Phila Pa 1976), 26(24), 2714-2718.

 

Mary Free Bed Physician/Staff Publications

Julia Craner, Ph.D., ABPP

Julia Craner is a clinical psychologist in the Mary Free Bed Pain Rehabilitation Program. She received her doctorate in Clinical Psychology from the University of Maine, completed an internship at VA Ann Arbor Healthcare System and a postdoctoral fellowship in Clinical Health Psychology at Mayo Clinic. She is board certified in behavioral and cognitive therapies. Her professional interests include pain rehabilitation, interdisciplinary care, somatic symptom disorders, anxiety disorders, insomnia and women’s health issues. Her research focuses on the ways people respond to and interpret physical and emotional changes, and how these processes impact health and well-being.

Martinson, M., Craner, J., & Clinton-Lont, J. (2019). Outcomes of a 6-week cognitive-behavioral therapy for chronic pain group for veterans seen in primary care. Translational Behavioral Medicine. Advance online publication. doi: 10.1093/tbm/iby127

Sawchuk, C.N., Craner, J.R., Berg, S.L., Smyth, K., Mack, J., Glader, M., Burke, L., Haggerty, S., Johnson, M., Miller, S., Sedivy, S., Morcomb, D., Heredia, D., Williams, M. W., & Katzelnick, D. J. (2018). Initial outcomes of a real-world multi-site primary care psychotherapy program. General Hospital Psychiatry, 54, 5-11.

Gilliam, W.P., Craner, J.R., Cunningham, J.L., Evans, M.M., Luedke, C.A., Morrison, E J., Sperry, J.A. and Loukianova, L.L. (2018). Longitudinal treatment outcomes for an interdisciplinary pain rehabilitation program: comparisons of subjective and objective outcomes based on opioid use status. Journal of Pain, 19(6), 678-689.

Haigh, E.A. P., Craner, J.R., Sigmon, S.T. and Thorpe, G.L. (2018). Symptom attributions across the menstrual cycle in women with panic disorder. Journal of Rational-Emotive & Cognitive-Behavior Therapy, 36(4), 320-332. Junghans-Rutelonis, A.N., Craner, J.R., Ale, C.M., Harbeck-Weber, C., Fischer, P. R. and Weiss, K.E. (2018). Youth with chronic pain and postural orthostatic tachycardia syndrome (POTS): treatment mediators of improvement in functional disability. Journal of Clinical Psychology in Medical Settings, 25(4), 471-484.

Koball, A.M., Mueller, P.M., Craner, J., Clark, M.M., Nanda, S., Kebede, E.B. and Grothe, K.B. (2018). Crucial conversations about weight management with health care providers: patients’ perspectives and experiences. Eating and Weight Disorders – Studies on Anorexia, Bulimia, and Obesity, 23(1), 87-94.

Craner, J., Sawchuk, C., Mack, J. and LeRoy, M. (2017). Development and implementation of a psychotherapy tracking database in primary care. Families, Systems, and Health, 35(2), 207-216.

Craner, J., Skillings, J. and Barnes, C. (2017). Obsessive compulsive disorder: under-recognized and responsive to treatment. Journal of Family Practice, 66(8), 503-506.

Craner, J., Sperry, J., Koball, A., Morrison, E. and Gilliam, W. (2017). Unique contributions of acceptance and catastrophizing on chronic pain adaptation. International Journal of Behavioral Medicine, 24(4), 542-551.

Craner, J., Vickers Douglas, K., Dierkhising, R., Hathaway, J. Goel, K. and Thomas, R. J. (2017). Associations of baseline depressed mood and happiness with subsequent wellbeing in cardiac patients. Social Science and Medicine, 174, 209-212.

Cunningham, J., Craner, J., Evans, M., Hooten, M. (2017). Benzodiazepine use in patients with chronic pain in an interdisciplinary pain rehabilitation program. Journal of Pain Research, 10, 311-317.

Gonzalez, C. A., Gentile, N. E., Angstman, K. B., Bonacci, R. P. and Craner, J. R. (2017). Exploration of residents’ relationships with faculty and team leads and their associations with resident wellness. Peer-Reviewed Reports in Medical Education (PRiMER), 1(5), 1-6.

Pestka, E., Craner, J., Evans, M., Nash, V., Kimondo, N., Pestka, D., Loukianova, L., Sperry, J. (2017). Impact of family history of substance us on opioid dose, depression, and pain catastrophizing in patients with chronic pain. Pain Management Nursing. Advance online publication. doi: 10.1016/j.pmn.2017.09.007

Sawchuk, C.N. and Craner, J. R. (2017). Evidence-based psychotherapy in primary care. FOCUS: The Journal of Lifelong Learning in Psychiatry, 15(3), 264-270.

Sawchuk, C. N., Roy-Byrne, P., Noonan, C., Craner, J. R., Goldberg, J., Manson, S., Buchwald, D. and AI-SUPERPFP Team. (2017). Panic attacks and panic disorder in the American Indian community.  Journal of Anxiety Disorders, 48, 6-12.

Shah, A., Craner, J. and Cunningham, J. (2017). Medical cannabis use among patients with chronic pain in an interdisciplinary pain rehabilitation program: characterization and treatment outcomes. Journal of Substance Abuse Treatment, 77, 95-100.

Craner, J., Gilliam, W. and Sperry, J. (2016). Rumination, magnification, and helplessness: how do different aspects of pain catastrophizing impact pain-related outcomes? The Clinical Journal of Pain, 32(12), 1028-1035.

Craner, J. and Sawchuk, C. (2016). Outcomes of a 6-week cognitive-behavioral and mindfulness group in primary care. Families, Systems, and Health, 34(3), 250-259.

Craner, J. R., Sigmon, S.T. and Young, M.A. (2016). The relationship between self-focused attention and menstrual cycle related symptoms among women with and without premenstrual disorders. Cognitive Therapy and Research, 40(1), 118-127.

Craner, J. R., Skipper, R.R., Gilliam, W.G., Morrison, E.J. and Sperry, J.A. (2016). Patients’ perceptions of a chronic pain rehabilitation program: changing the conversation. Current Medical Research and Opinion, 32(5), 879-883.

Craner, J., Sperry, J. and Evans, M. (2016). The relationship between pain catastrophizing and outcomes of a 3-week comprehensive pain rehabilitation program. Pain Medicine, 17(11), 2026-2035.

Gilliam, W. P., Craner, J. R., Morrison, E. J. and Sperry, J. A. (2016). The mediating effects of different dimensions of pain catastrophizing on outcomes in an interdisciplinary pain rehabilitation program. The Clinical Journal of Pain, 33(5), 443-451.

Koball, A., Craner, J. and Sperry, J. (2016). Impact of weight status on physical and psychological outcomes of a comprehensive pain rehabilitation program. Journal of Rehabilitation Medicine, 48, 632-635.

Martinson, A., Craner, J. and Sigmon, S. (2016). Cortisol reactivity to an intimacy induction task among women survivors of sexual trauma. Psychoneurocrinology, 65, 118-126.

Craner, J., Martinson, A., Sigmon, S. and McGillicuddy, M. (2015). Prevalence of childhood sexual abuse among first year college students based on behaviorally-specific assessment. Journal of Child Sexual Abuse, 24(5), 484-505.

Craner, J., Sigmon, S. and Martinson, A. (2015). Self-focused attention in response to laboratory stressors among women with premenstrual disorders. Archives of Women’s Mental Health, 18(4), 595-606.

Craner, J. Sigmon, S.T., Martinson, A. and McGillicuddy, M. (2014). Rumination and premenstrual disorders. Journal of Clinical Psychology, 70(1), 32-47.

Craner, J., Sigmon, S. T. and McGillicuddy, M. (2014). Is there a disconnect between research and practice in PMDD diagnostic procedures? Women & Health, 54(3), 232-244.

Whitcomb-Smith, S., Sigmon, S.T., Martinson, A., Young, M., Craner, J. and Boulard, N. (2014). The temporal development of mood, cognitive and vegetative symptoms in recurrent SAD episodes: a test of the Dual Vulnerability Hypothesis. Cognitive Therapy and Research, 38(1), 43-54.

Craner, J., Sigmon, S.T., Martinson, A. and McGillicuddy, M. (2013). Perceptions of health and somatic sensations in women reporting premenstrual dysphoric disorder (PMDD) and premenstrual syndrome (PMS). Journal of Nervous and Mental Disease, 201(9), 780-785.

Martinson, A., Sigmon, S.T., Craner, J., Rothstein, E., & McGillicuddy, M. (2013). Processing of intimacy-related stimuli in survivors of sexual trauma: The role of PTSD. Journal of Interpersonal Violence, 28(9), 1886-1908.

Craner, J., Sigmon, S.T., Martinson, A. and Yoon, K. L. (2012). Experiential avoidance and attention to emotional stimuli. International Journal of Advances in Psychology, 1(3), 68-74.

Lodis, C., Sigmon, S.T., Martinson, A., Craner, J., McGillicuddy, M. and Hale, B. (2012). Is collegiate athletic participation a protective factor in seasonality? Journal of Clinical Sport Psychology, 6, 113-128.

 

Jacobus Donders, Ph.D., ABPP

Jacobus Donders is chief psychologist at Mary Free Bed Rehabilitation Hospital. He received his doctorate at the University of Windsor and has academic affiliations with the Adler School of Professional Psychology and Michigan State University College of Human Medicine. He is a fellow at the American Psychological Association (Divisions 22 and 40), the Michigan Psychological Association and the National Academy of Neuropsychology. He is a member of the American Psychological Association (Division 54) and the International Neuropsychological Society. He is the recipient of the 2012 Diller Award. He has over 100 peer-reviewed journal publications; the most recent are listed below:

Anderson, L.B., Jaroh, R., Smith, H., Strong, C.A. and Donders, J. (2017). Criterion validity of the D–KEFS color-word and verbal fluency switching paradigms following traumatic brain injury.  Journal of Clinical and Experimental Neuropsychology, 39, 890-899.

Asbell, S., Donders, J., Van Tubbergen, M. and Warschausky, S. (2010). Predictors of reading comprehension in children with cerebral palsy and typically developing children. Child Neuropsychology, 16, 313-325.

Byerley, A.K. and Donders, J. (2013). Clinical utility of the Behavior Rating Inventory of Executive Function — Self Report (BRIEF–SR) in adolescents with traumatic brain injury. Rehabilitation Psychology, 58, 412-421.

DeJong, J. and Donders, J. (2009). A confirmatory factor analysis of the California Verbal Learning Test — Second Edition (CVLT–II) in a traumatic brain injury sample. Assessment, 16, 328-336.

DeJong, J., & Donders, J. (2010). Cluster subtypes on the California Verbal Learning Test—Second Edition (CVLT–II) in a traumatic brain injury sample. Journal of Clinical and Experimental Neuropsychology, 32, 953-960.

Donders, J. (2013). Ethical issues in pediatric traumatic brain injury rehabilitation. Journal of Head Trauma Rehabilitation, 28, 485-488.

Donders, J. (2017). Civil capacity in transition-age youth with history of central nervous system compromise. The Clinical Neuropsychologist, 31, 501-514.

Donders, J., DenBraber, D. and Vos, L. (2010).  Construct and criterion validity of the Behavioral Rating Inventory of Executive Function (BRIEF) in children referred for neuropsychological assessment after pediatric traumatic brain injury. Journal of Neuropsychology, 4, 197-209.

Donders, J., & DeWit, C. (2017).  Parental ratings of daily behavior and child cognitive test performance after pediatric mild traumatic brain injury.  Child Neuropsychology, 23, 554-570.

Donders, J., Elzinga, B., Kuipers, D., Helder, E., & Crawford, J. R. (2013).  Development of an eight-subtest short form of the WISC–IV and evaluation of its clinical utility in children with traumatic brain injury.  Child Neuropsychology, 19, 662-670.

Donders, J. and Larsen, T. (2012).  Clinical utility of the Tower of London – Drexel University, Second Edition (TOLDX) after adolescent traumatic brain injury. Developmental Neuropsychology, 37, 333-342.

Donders, J. and Levitt, T. (2012).  Criterion validity of the Neuropsychological Assessment Battery after traumatic brain injury. Archives of Clinical Neuropsychology, 27, 440-445.

Donders, J., Mullarkey, K and Allchin, J. (2009). Congenital bilateral perisylvian syndrome: A case study.  The Clinical Neuropsychologist, 23, 276-285.

Donders, J., Oh, Y.I. and Gable, J. (2015).  Self and informant ratings of executive functioning after mild traumatic brain injury. Journal of Head Trauma Rehabilitation, 30, E30-E39.

Donders, J. and Pendery, A. (2017).  Clinical utility of the Patient Health Questionnaire–9 in the assessment of major depression after broad-spectrum traumatic brain injury. Archives of Physical Medicine & Rehabilitation, 98, 2514-2519.

Donders, J. and Stout, J. (2019).  The influence of cognitive reserve on recovery from traumatic brain injury. Archives of Clinical Neuropsychology, 34, 206-213.

Donders, J. and Strong, C.A.H. (2011).  Embedded effort indicators on the California Verbal Learning Test—Second Edition (CVLT–II): An attempted cross-validation. The Clinical Neuropsychologist, 25, 173-184.

Donders, J. and Strong, C.A.H. (2013). Does Green’s Word Memory Test really measure memory?  Journal of Clinical and Experimental Neuropsychology, 35, 827-834.

Donders, J. and Strong, C.A.H. (2015). Clinical utility of the Wechsler Adult Intelligence Scale — Fourth Edition after traumatic brain injury.  Assessment, 22, 17-22.

Donders, J. and Strong, C.A.H. (2016). Latent structure of the Behavior Rating Inventory of Executive Function—Adult Version (BRIEF–A) after mild traumatic brain injury.  Archives of Clinical Neuropsychology, 31, 29-36.

Donders, J. and Taneja, C. (2009). Neurobehavioral characteristics of children with Duchenne Muscular Dystrophy.  Child Neuropsychology, 15, 295-304.

Johnson, V.M. and Donders, J. (2018). Correlates of verbal learning and memory after pediatric traumatic brain injury. Applied Neuropsychology: Child, 7, 298-305.

Kahn, D.A., Asbell, S.J. and Donders, J. (2015). Clinical utility of the LANSE–A in adolescents with traumatic brain injury. Rehabilitation Psychology, 60, 187-192.

Kaufman, J.N., Donders, J. and Warschausky, S. (2014). A comparison of visual inspection time measures in children with cerebral palsy. Rehabilitation Psychology, 59, 147-154.

Krishnan, M. and Donders, J. (2011).  Embedded assessment of validity using the Continuous Visual Memory Test in patients with traumatic brain injury.  Archives of Clinical Neuropsychology, 26, 176-183.

Krishnan, M., Smith, N. and Donders, J. (2012).  Use of the Tower of London – Drexel University, Second Edition (TOLDX) in adults with traumatic brain injury.  The Clinical Neuropsychologist, 26, 951-964.

Leininger, S., Strong, C.A.H. and Donders, J. (2014).  Predictors of outcome after treatment of mild traumatic brain injury: A pilot study.  Journal of Head Trauma Rehabilitation, 29, 109-116.

Scott, K. L., Strong, C.A.H., Gorter, B. and Donders, J. (2016). Predictors of post-concussion rehabilitation outcomes at three-month follow-up. The Clinical Neuropsychologist, 30, 66-81.

Strong, C.A.H., Tiesma, D. and Donders, J. (2011).  Criterion validity of the Delis-Kaplan Executive Function System (D-KEFS) fluency subtests after traumatic brain injury.  Journal of the International Neuropsychological Society, 17, 230-237.

Stucky, K.J., Bush, S. and Donders, J. (2010).  Providing effective supervision in clinical neuropsychology.  The Clinical Neuropsychologist, 24, 737-758.

Warschausky, S., Van Tubbergen, M., Asbell, S., Kaufman, J., Ayyangar, R. and Donders, J. (2012).  Modified test administration using assistive technology: Preliminary psychometric findings. Assessment, 19, 472-479.

Wilson, K.R., Donders, J. and Nguyen, L. (2011).  Self and parent ratings of executive functioning after adolescent traumatic brain injury. Rehabilitation Psychology, 56, 100-106.